Certain nicotine flavors could be more addictive than others, according to researchers from the Yale School of Medicine, who found that rats preferred the combination of flavorings and nicotine to just the flavorings or unflavored nicotine on their own. The study suggests that sweeteners play a greater role in nicotine preference for females, while flavors are more influential for males.
Published in the journal Nicotine & Tobacco Research, the effects of the sweeteners sucrose and saccharin, as well as the commonly used flavor additive cinnamaldehyde (the principal chemical of cinnamon) in nicotine were tested on rats. Female rats showed the highest nicotine preference when combined with sucrose, while males preferred nicotine combined with cinnamon. They also found menthol flavoring increases oral nicotine intake in male rats but not in females.
The study says that although flavors do not significantly impact nicotine absorption, they significantly influence user satisfaction and increase the likelihood that people will continue using nicotine products.
